Inhibitors of HGFA, Matriptase, and Hepsin Serine Proteases: A Nonkinase Strategy to Block Cell Signaling in Cancer

[Image: see text] Hepatocyte growth factor activators (HGFA), matriptase, and hepsin are S1 family trypsin-like serine proteases. These proteases proteolytically cleave the single-chain zymogen precursors, pro-HGF (hepatocyte growth factor), and pro-MSP (macrophage stimulating protein) into active h...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Han, Zhenfu, Harris, Peter K. W., Jones, Darin E., Chugani, Ryan, Kim, Tommy, Agarwal, Manjula, Shen, Wei, Wildman, Scott A., Janetka, James W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4233366/
https://ncbi.nlm.nih.gov/pubmed/25408834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml500254r
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