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Structure-Based Drug Design and Optimization of Mannoside Bacterial FimH Antagonists
FimH-mediated cellular adhesion to mannosylated proteins is critical in the ability of uropathogenic E. coli (UPEC) to colonize and invade the bladder epithelium during urinary tract infection. We describe the discovery and optimization of potent small-molecule FimH bacterial adhesion antagonists ba...
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| Autors principals: | , , , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2010
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2894565/ https://ncbi.nlm.nih.gov/pubmed/20507142 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm100438s |
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