Structure-Based Drug Design and Optimization of Mannoside Bacterial FimH Antagonists

FimH-mediated cellular adhesion to mannosylated proteins is critical in the ability of uropathogenic E. coli (UPEC) to colonize and invade the bladder epithelium during urinary tract infection. We describe the discovery and optimization of potent small-molecule FimH bacterial adhesion antagonists ba...

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Bibliografiset tiedot
Päätekijät: Han, Zhenfu, Pinkner, Jerome S., Ford, Bradley, Obermann, Robert, Nolan, William, Wildman, Scott A., Hobbs, Doug, Ellenberger, Tom, Cusumano, Corinne K., Hultgren, Scott J., Janetka, James W.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2010
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2894565/
https://ncbi.nlm.nih.gov/pubmed/20507142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm100438s
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