Structure-based discovery of glycomimetic FmlH ligands as inhibitors of bacterial adhesion during urinary tract infection

Treatment of bacterial infections is becoming a serious clinical challenge due to the global dissemination of multidrug antibiotic resistance, necessitating the search for alternative treatments to disarm the virulence mechanisms underlying these infections. Uropathogenic Escherichia coli (UPEC) emp...

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Bibliografische gegevens
Gepubliceerd in:Proc Natl Acad Sci U S A
Hoofdauteurs: Kalas, Vasilios, Hibbing, Michael E., Maddirala, Amarendar Reddy, Chugani, Ryan, Pinkner, Jerome S., Mydock-McGrane, Laurel K., Conover, Matt S., Janetka, James W., Hultgren, Scott J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2018
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PNAS Plus
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5866590/
https://ncbi.nlm.nih.gov/pubmed/29507247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1720140115
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