Allosteric HIV‐1 integrase inhibitors promote aberrant protein multimerization by directly mediating inter‐subunit interactions: Structural and thermodynamic modeling studies

Allosteric HIV‐1 integrase (IN) inhibitors (ALLINIs) bind at the dimer interface of the IN catalytic core domain (CCD), and potently inhibit HIV‐1 by promoting aberrant, higher‐order IN multimerization. Little is known about the structural organization of the inhibitor‐induced IN multimers and impor...

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Vydáno v:Protein Sci
Hlavní autoři: Deng, Nanjie, Hoyte, Ashley, Mansour, Yara E., Mohamed, Mosaad S., Fuchs, James R., Engelman, Alan N., Kvaratskhelia, Mamuka, Levy, Ronald
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2016
Témata:
Accelerated Communications
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5079246/
https://ncbi.nlm.nih.gov/pubmed/27503276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2997
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