The A128T Resistance Mutation Reveals Aberrant Protein Multimerization as the Primary Mechanism of Action of Allosteric HIV-1 Integrase Inhibitors

Allosteric HIV-1 integrase (IN) inhibitors (ALLINIs) are a very promising new class of anti-HIV-1 agents that exhibit a multimodal mechanism of action by allosterically modulating IN multimerization and interfering with IN-lens epithelium-derived growth factor (LEDGF)/p75 binding. Selection of viral...

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Bibliographic Details
Main Authors: Feng, Lei, Sharma, Amit, Slaughter, Alison, Jena, Nivedita, Koh, Yasuhiro, Shkriabai, Nikolozi, Larue, Ross C., Patel, Pratiq A., Mitsuya, Hiroaki, Kessl, Jacques J., Engelman, Alan, Fuchs, James R., Kvaratskhelia, Mamuka
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2013
Subjects:
Molecular Bases of Disease
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3668738/
https://ncbi.nlm.nih.gov/pubmed/23615903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.443390
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