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HIV-1 Integrase Multimerization as a Therapeutic Target

Multimeric HIV-1 integrase (IN) plays an essential, multifunctional role in virus replication and serves as an important therapeutic target. Structural and biochemical studies have revealed the importance of the ordered interplay between IN molecules for its function. In the presence of viral DNA en...

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Détails bibliographiques
Publié dans:Curr Top Microbiol Immunol
Auteurs principaux: Feng, Lei, Larue, Ross C., Slaughter, Alison, Kessl, Jacques J., Kvaratskhelia, Mamuka
Format: Artigo
Langue:Inglês
Publié: 2015
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4791179/
https://ncbi.nlm.nih.gov/pubmed/25778682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/82_2015_439
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