A Critical Role of the C-terminal Segment for Allosteric Inhibitor-induced Aberrant Multimerization of HIV-1 Integrase

Allosteric HIV-1 integrase (IN) inhibitors (ALLINIs) are a promising class of antiretroviral agents for clinical development. Although ALLINIs promote aberrant IN multimerization and inhibit IN interaction with its cellular cofactor LEDGF/p75 with comparable potencies in vitro, their primary mechani...

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Detalhes bibliográficos
Main Authors: Shkriabai, Nikoloz, Dharmarajan, Venkatasubramanian, Slaughter, Alison, Kessl, Jacques J., Larue, Ross C., Feng, Lei, Fuchs, James R., Griffin, Patrick R., Kvaratskhelia, Mamuka
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4176244/
https://ncbi.nlm.nih.gov/pubmed/25118283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.589572
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