A Critical Role of the C-terminal Segment for Allosteric Inhibitor-induced Aberrant Multimerization of HIV-1 Integrase

Allosteric HIV-1 integrase (IN) inhibitors (ALLINIs) are a promising class of antiretroviral agents for clinical development. Although ALLINIs promote aberrant IN multimerization and inhibit IN interaction with its cellular cofactor LEDGF/p75 with comparable potencies in vitro, their primary mechani...

Descripció completa

Guardat en:
Dades bibliogràfiques
Autors principals: Shkriabai, Nikoloz, Dharmarajan, Venkatasubramanian, Slaughter, Alison, Kessl, Jacques J., Larue, Ross C., Feng, Lei, Fuchs, James R., Griffin, Patrick R., Kvaratskhelia, Mamuka
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2014
Matèries:
Molecular Bases of Disease
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4176244/
https://ncbi.nlm.nih.gov/pubmed/25118283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.589572
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars