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Allosteric inhibition of HIV-1 integrase activity
HIV-1 integrase is an important therapeutic target in the fight against HIV/AIDS. Integrase strand transfer inhibitors (INSTIs), which target the enzyme active site, have witnessed clinical success over the past 5 years, but the generation of drug resistance poses challenges to INSTI-based therapies...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3679204/ https://ncbi.nlm.nih.gov/pubmed/23647983 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cbpa.2013.04.010 |
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