An Allosteric Mechanism for Inhibiting HIV-1 Integrase with a Small Molecule

HIV-1 integrase (IN) is a validated target for developing antiretroviral inhibitors. Using affinity acetylation and mass spectrometric (MS) analysis, we previously identified a tetra-acetylated inhibitor (2E)-3-[3,4-bis(acetoxy)phenyl]-2-propenoate-N-[(2E)-3-[3,4-bis(acetyloxy)phenyl]-1-oxo-2-propen...

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Hlavní autoři: Kessl, Jacques J., Eidahl, Jocelyn O., Shkriabai, Nikolozi, Zhao, Zhuojun, McKee, Christopher J., Hess, Sonja, Burke, Terrence R., Kvaratskhelia, Mamuka
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society for Pharmacology and Experimental Therapeutics 2009
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2769043/
https://ncbi.nlm.nih.gov/pubmed/19638533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.109.058883
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