Multimode, Cooperative Mechanism of Action of Allosteric HIV-1 Integrase Inhibitors

The multifunctional HIV-1 enzyme integrase interacts with viral DNA and its key cellular cofactor LEDGF to effectively integrate the reverse transcript into a host cell chromosome. These interactions are crucial for HIV-1 replication and present attractive targets for antiviral therapy. Recently, 2-...

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Detalhes bibliográficos
Main Authors: Kessl, Jacques J., Jena, Nivedita, Koh, Yasuhiro, Taskent-Sezgin, Humeyra, Slaughter, Alison, Feng, Lei, de Silva, Suresh, Wu, Li, Le Grice, Stuart F. J., Engelman, Alan, Fuchs, James R., Kvaratskhelia, Mamuka
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3351293/
https://ncbi.nlm.nih.gov/pubmed/22437836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.354373
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