Allosteric integrase inhibitor potency is determined through the inhibition of HIV-1 particle maturation

Integration is essential for HIV-1 replication, and the viral integrase (IN) protein is an important therapeutic target. Allosteric IN inhibitors (ALLINIs) that engage the IN dimer interface at the binding site for the host protein lens epithelium-derived growth factor (LEDGF)/transcriptional coacti...

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Detalhes bibliográficos
Main Authors: Jurado, Kellie A., Wang, Hao, Slaughter, Alison, Feng, Lei, Kessl, Jacques J., Koh, Yasuhiro, Wang, Weifeng, Ballandras-Colas, Allison, Patel, Pratiq A., Fuchs, James R., Kvaratskhelia, Mamuka, Engelman, Alan
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3666754/
https://ncbi.nlm.nih.gov/pubmed/23610442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1300703110
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