The mechanism of H171T resistance reveals the importance of N(δ)-protonated His171 for the binding of allosteric inhibitor BI-D to HIV-1 integrase

BACKGROUND: Allosteric HIV-1 integrase (IN) inhibitors (ALLINIs) are an important new class of anti-HIV-1 agents. ALLINIs bind at the IN catalytic core domain (CCD) dimer interface occupying the principal binding pocket of its cellular cofactor LEDGF/p75. Consequently, ALLINIs inhibit HIV-1 IN inter...

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Detalhes bibliográficos
Publicado no:Retrovirology
Main Authors: Slaughter, Alison, Jurado, Kellie A, Deng, Nanjie, Feng, Lei, Kessl, Jacques J, Shkriabai, Nikoloz, Larue, Ross C, Fadel, Hind J, Patel, Pratiq A, Jena, Nivedita, Fuchs, James R, Poeschla, Eric, Levy, Ronald M, Engelman, Alan, Kvaratskhelia, Mamuka
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4251946/
https://ncbi.nlm.nih.gov/pubmed/25421939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12977-014-0100-1
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