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Multimodal mechanism of action of allosteric HIV-1 integrase inhibitors
Integrase (IN) is required for lentivirus replication and is a proven drug target for the prevention of AIDS in HIV-1 infected patients. While clinical strand transfer inhibitors disarm the IN active site, allosteric inhibition of enzyme activity through the disruption of IN-IN protein interfaces ho...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3919682/ https://ncbi.nlm.nih.gov/pubmed/24274067 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1017/erm.2013.15 |
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