Allosteric HIV‐1 integrase inhibitors promote aberrant protein multimerization by directly mediating inter‐subunit interactions: Structural and thermodynamic modeling studies

Allosteric HIV‐1 integrase (IN) inhibitors (ALLINIs) bind at the dimer interface of the IN catalytic core domain (CCD), and potently inhibit HIV‐1 by promoting aberrant, higher‐order IN multimerization. Little is known about the structural organization of the inhibitor‐induced IN multimers and impor...

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Detalhes bibliográficos
Publicado no:Protein Sci
Main Authors: Deng, Nanjie, Hoyte, Ashley, Mansour, Yara E., Mohamed, Mosaad S., Fuchs, James R., Engelman, Alan N., Kvaratskhelia, Mamuka, Levy, Ronald
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Accelerated Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5079246/
https://ncbi.nlm.nih.gov/pubmed/27503276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2997
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