Allosteric HIV‐1 integrase inhibitors promote aberrant protein multimerization by directly mediating inter‐subunit interactions: Structural and thermodynamic modeling studies

Allosteric HIV‐1 integrase (IN) inhibitors (ALLINIs) bind at the dimer interface of the IN catalytic core domain (CCD), and potently inhibit HIV‐1 by promoting aberrant, higher‐order IN multimerization. Little is known about the structural organization of the inhibitor‐induced IN multimers and impor...

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Detaylı Bibliyografya
Yayımlandı:Protein Sci
Asıl Yazarlar: Deng, Nanjie, Hoyte, Ashley, Mansour, Yara E., Mohamed, Mosaad S., Fuchs, James R., Engelman, Alan N., Kvaratskhelia, Mamuka, Levy, Ronald
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: John Wiley and Sons Inc. 2016
Konular:
Accelerated Communications
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5079246/
https://ncbi.nlm.nih.gov/pubmed/27503276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2997
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