Allosteric HIV‐1 integrase inhibitors promote aberrant protein multimerization by directly mediating inter‐subunit interactions: Structural and thermodynamic modeling studies

od Deng, Nanjie, Hoyte, Ashley, Mansour, Yara E., Mohamed, Mosaad S., Fuchs, James R., Engelman, Alan N., Kvaratskhelia, Mamuka, Levy, Ronald
izdano v Protein Sci (2016)

Computational and synthetic approaches for developing Lavendustin B derivatives as allosteric inhibitors of HIV-1 integrase

od Agharbaoui, Fatima E., Hoyte, Ashley C., Ferro, Stefania, Gitto, Rosaria, Buemi, Maria Rosa, Fuchs, James R., Kvaratskhelia, Mamuka, De Luca, Laura
izdano v Eur J Med Chem (2016)

Resistance to pyridine-based inhibitor KF116 reveals an unexpected role of integrase in HIV-1 Gag-Pol polyprotein proteolytic processing

od Hoyte, Ashley C., Jamin, Augusta V., Koneru, Pratibha C., Kobe, Matthew J., Larue, Ross C., Fuchs, James R., Engelman, Alan N., Kvaratskhelia, Mamuka
izdano v J Biol Chem (2017)

The Competitive Interplay between Allosteric HIV-1 Integrase Inhibitor BI/D and LEDGF/p75 during the Early Stage of HIV-1 Replication Adversely Affects Inhibitor Potency

od Feng, Lei, Dharmarajan, Venkatasubramanian, Serrao, Erik, Hoyte, Ashley, Larue, Ross C., Slaughter, Alison, Sharma, Amit, Plumb, Matthew R., Kessl, Jacques J., Fuchs, James R., Bushman, Frederic D., Engelman, Alan N., Griffin, Patrick R., Kvaratskhelia, Mamuka
izdano v ACS Chem Biol (2016)

HIV-1 integrase tetramers are the antiviral target of pyridine-based allosteric integrase inhibitors

od Koneru, Pratibha C, Francis, Ashwanth C, Deng, Nanjie, Rebensburg, Stephanie V, Hoyte, Ashley C, Lindenberger, Jared, Adu-Ampratwum, Daniel, Larue, Ross C, Wempe, Michael F, Engelman, Alan N, Lyumkis, Dmitry, Fuchs, James R, Levy, Ronald M, Melikyan, Gregory B, Kvaratskhelia, Mamuka
izdano v eLife (2019)