Allosteric HIV‐1 integrase inhibitors promote aberrant protein multimerization by directly mediating inter‐subunit interactions: Structural and thermodynamic modeling studies

Allosteric HIV‐1 integrase (IN) inhibitors (ALLINIs) bind at the dimer interface of the IN catalytic core domain (CCD), and potently inhibit HIV‐1 by promoting aberrant, higher‐order IN multimerization. Little is known about the structural organization of the inhibitor‐induced IN multimers and impor...

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Bibliographische Detailangaben
Veröffentlicht in:Protein Sci
Hauptverfasser: Deng, Nanjie, Hoyte, Ashley, Mansour, Yara E., Mohamed, Mosaad S., Fuchs, James R., Engelman, Alan N., Kvaratskhelia, Mamuka, Levy, Ronald
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2016
Schlagworte:
Accelerated Communications
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5079246/
https://ncbi.nlm.nih.gov/pubmed/27503276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2997
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