Iterative structure-based improvement of a respiratory syncytial virus fusion glycoprotein vaccine

Structure-based design of vaccines has been a long-sought goal, especially the iterative optimization used so successfully with structure-based design of drugs. We previously developed a 1st-generation vaccine antigen called DS-Cav1, comprising a pre-fusion-stabilized form of the fusion (F) glycopro...

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Publicado no:Nat Struct Mol Biol
Main Authors: Joyce, M. Gordon, Zhang, Baoshan, Ou, Li, Chen, Man, Chuang, Gwo-Yu, Druz, Aliaksandr, Kong, Wing-Pui, Lai, Yen-Ting, Rundlet, Emily J., Tsybovsky, Yaroslav, Yang, Yongping, Georgiev, Ivelin S., Guttman, Miklos, Lees, Christopher R., Pancera, Marie, Sastry, Mallika, Soto, Cinque, Stewart-Jones, Guillaume B.E., Thomas, Paul V., Van Galen, Joseph G., Baxa, Ulrich, Lee, Kelly K., Mascola, John R., Graham, Barney S., Kwong, Peter D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5016229/
https://ncbi.nlm.nih.gov/pubmed/27478931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.3267
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