A Cysteine Zipper Stabilizes a Pre-Fusion F Glycoprotein Vaccine for Respiratory Syncytial Virus

Recombinant subunit vaccines should contain minimal non-pathogen motifs to reduce potential off-target reactivity. We recently developed a vaccine antigen against respiratory syncytial virus (RSV), which comprised the fusion (F) glycoprotein stabilized in its pre-fusion trimeric conformation by “DS-...

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Udgivet i:PLoS One
Main Authors: Stewart-Jones, Guillaume B. E., Thomas, Paul V., Chen, Man, Druz, Aliaksandr, Joyce, M. Gordon, Kong, Wing-Pui, Sastry, Mallika, Soto, Cinque, Yang, Yongping, Zhang, Baoshan, Chen, Lei, Chuang, Gwo-Yu, Georgiev, Ivelin S., McLellan, Jason S., Srivatsan, Sanjay, Zhou, Tongqing, Baxa, Ulrich, Mascola, John R., Graham, Barney S., Kwong, Peter D.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4476739/
https://ncbi.nlm.nih.gov/pubmed/26098893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0128779
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