Crystal Structure and Immunogenicity of the DS-Cav1-Stabilized Fusion Glycoprotein From Respiratory Syncytial Virus Subtype B

BACKGROUND: Respiratory syncytial virus (RSV) subtypes, A and B, co-circulate in annual epidemics and alternate in dominance. We have shown that a subtype A RSV fusion (F) glycoprotein, stabilized in its prefusion conformation by DS-Cav1 mutations, is a promising RSV-vaccine immunogen, capable of bo...

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Detalhes bibliográficos
Publicado no:Pathog Immun
Main Authors: Joyce, M. Gordon, Bao, Amy, Chen, Man, Georgiev, Ivelin S., Ou, Li, Bylund, Tatsiana, Druz, Aliaksandr, Kong, Wing-Pui, Peng, Dongjun, Rundlet, Emily J., Van Galen, Joseph G., Wang, Shuishu, Yang, Yongping, Zhang, Baoshan, Chuang, Gwo-Yu, McLellan, Jason S., Graham, Barney S., Mascola, John R., Kwong, Peter D.
Formato: Artigo
Idioma:Inglês
Publicado em: Pathogens and Immunity 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6922093/
https://ncbi.nlm.nih.gov/pubmed/31893251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.20411/pai.v4i2.338
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