Oncogenic deregulation of EZH2 as an opportunity for targeted therapy in lung cancer

As a master regulator of chromatin function, the lysine methyltransferase EZH2 orchestrates transcriptional silencing of developmental gene networks. Overexpression of EZH2 is commonly observed in human epithelial cancers, such as non-small cell lung carcinoma (NSCLC), yet definitive demonstration o...

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Vydáno v:Cancer Discov
Hlavní autoři: Zhang, Haikuo, Qi, Jun, Reyes, Jaime M., Li, Lewyn, Rao, Prakash K., Li, Fugen, Lin, Charles Y., Perry, Jennifer A., Lawlor, Matthew A., Federation, Alexander, De Raedt, Thomas, Li, Yvonne Y., Liu, Yan, Duarte, Melissa A., Zhang, Yanxi, Herter-Sprie, Grit S., Kikuchi, Eiki, Carretero, Julian, Perou, Charles M., Reibel, Jacob B., Paulk, Joshiawa, Bronson, Roderick T., Watanabe, Hideo, Fillmore, Christine M., Kim, Carla F., Hammerman, Peter S., Brown, Myles, Cichowski, Karen, Long, Henry, Bradner, James E., Wong, Kwok-Kin
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5010480/
https://ncbi.nlm.nih.gov/pubmed/27312177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-16-0164
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