An oncogenic Ezh2 mutation cooperates with particular genetic alterations to induce tumors in mice and redistributes H3K27 trimethylation throughout the genome

B-cell lymphoma and melanoma harbor recurrent mutations in the gene encoding the EZH2 histone methyltransferase, but the carcinogenic role of these mutations is unclear. Here we describe a mouse model in which the most common somatic EZH2 gain-of-function mutation (Y646F in human, Y641F in the mouse...

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Veröffentlicht in:Nat Med
Hauptverfasser: Souroullas, George P., Jeck, William R., Parker, Joel S., Simon, Jeremy M., Liu, Jie-Yu, Paulk, Joshiawa, Xiong, Jessie, Clark, Kelly S., Fedoriw, Yuri, Qi, Jun, Burd, Christin E., Bradner, James E., Sharpless, Norman E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4899144/
https://ncbi.nlm.nih.gov/pubmed/27135738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.4092
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