A carregar...
An oncogenic Ezh2 mutation cooperates with particular genetic alterations to induce tumors in mice and redistributes H3K27 trimethylation throughout the genome
B-cell lymphoma and melanoma harbor recurrent mutations in the gene encoding the EZH2 histone methyltransferase, but the carcinogenic role of these mutations is unclear. Here we describe a mouse model in which the most common somatic EZH2 gain-of-function mutation (Y646F in human, Y641F in the mouse...
Na minha lista:
| Publicado no: | Nat Med |
|---|---|
| Main Authors: | , , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
|
| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4899144/ https://ncbi.nlm.nih.gov/pubmed/27135738 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.4092 |
| Tags: |
Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!
|