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Lkb1 deletion in murine B lymphocytes promotes cell death and cancer
LKB1 (aka STK11) is a potent tumor suppressor in solid tumors such as melanoma and lung adenocarcinoma, but inactivation in hematopoietic cells causes cell death, without signs of tumorigenesis. We noted somatic LKB1 deletion or mutation at low frequency in human B cell lymphoma. In order to determi...
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| Udgivet i: | Exp Hematol |
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| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2017
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5554940/ https://ncbi.nlm.nih.gov/pubmed/28435024 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exphem.2017.04.005 |
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