A murine model of chronic lymphocytic leukemia based on B cell-restricted expression of Sf3b1 mutation and Atm deletion

SF3B1 is recurrently mutated in chronic lymphocytic leukemia (CLL), but its role in the pathogenesis of CLL remain elusive. Here, we show that conditional expression of Sf3b1-K700E mutation in mouse B cells disrupts pre-mRNA splicing, alters cell development, and induces a state of cellular senescen...

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Bibliografske podrobnosti
izdano v:Cancer Cell
Main Authors: Yin, Shanye, Gambe, Rutendo G., Sun, Jing, Martinez, Aina Zurita, Cartun, Zachary J., Regis, Fara Faye D., Wan, Youzhong, Fan, Jean, Brooks, Angela N., Herman, Sarah E.M., Hacken, Elisa ten, Taylor-Weiner, Amaro, Rassenti, Laura Z., Ghia, Emanuela M., Kipps, Thomas J., Obeng, Esther A., Cibulskis, Carrie L., Neuberg, Donna, Campagna, Dean R., Fleming, Mark D., Ebert, Benjamin L., Wiestner, Adrian, Leshchiner, Ignaty, DeCaprio, James A., Getz, Gad, Reed, Robin, Carrasco, Ruben D., Wu, Catherine J., Wang, Lili
Format: Artigo
Jezik:Inglês
Izdano: 2019
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6372356/
https://ncbi.nlm.nih.gov/pubmed/30712845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2018.12.013
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