A murine model of chronic lymphocytic leukemia based on B cell-restricted expression of Sf3b1 mutation and Atm deletion

SF3B1 is recurrently mutated in chronic lymphocytic leukemia (CLL), but its role in the pathogenesis of CLL remain elusive. Here, we show that conditional expression of Sf3b1-K700E mutation in mouse B cells disrupts pre-mRNA splicing, alters cell development, and induces a state of cellular senescen...

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Pubblicato in:Cancer Cell
Autori principali: Yin, Shanye, Gambe, Rutendo G., Sun, Jing, Martinez, Aina Zurita, Cartun, Zachary J., Regis, Fara Faye D., Wan, Youzhong, Fan, Jean, Brooks, Angela N., Herman, Sarah E.M., Hacken, Elisa ten, Taylor-Weiner, Amaro, Rassenti, Laura Z., Ghia, Emanuela M., Kipps, Thomas J., Obeng, Esther A., Cibulskis, Carrie L., Neuberg, Donna, Campagna, Dean R., Fleming, Mark D., Ebert, Benjamin L., Wiestner, Adrian, Leshchiner, Ignaty, DeCaprio, James A., Getz, Gad, Reed, Robin, Carrasco, Ruben D., Wu, Catherine J., Wang, Lili
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6372356/
https://ncbi.nlm.nih.gov/pubmed/30712845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2018.12.013
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