EZH1 and EZH2 cogovern histone H3K27 trimethylation and are essential for hair follicle homeostasis and wound repair

Polycomb protein group (PcG)-dependent trimethylation on H3K27 (H3K27me3) regulates identity of embryonic stem cells (ESCs). How H3K27me3 governs adult SCs and tissue development is unclear. Here, we conditionally target H3K27 methyltransferases Ezh2 and Ezh1 to address their roles in mouse skin hom...

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Détails bibliographiques
Auteurs principaux: Ezhkova, Elena, Lien, Wen-Hui, Stokes, Nicole, Pasolli, H. Amalia, Silva, Jose M., Fuchs, Elaine
Format: Artigo
Langue:Inglês
Publié: Cold Spring Harbor Laboratory Press 2011
Sujets:
Research Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3049289/
https://ncbi.nlm.nih.gov/pubmed/21317239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.2019811
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