Structural Basis for Nucleotide Exchange in Heterotrimeric G Proteins

G protein–coupled receptors (GPCRs) relay diverse extracellular signals into cells by catalyzing nucleotide release from heterotrimeric G proteins, but the mechanism underlying this quintessential molecular signaling event has remained unclear. Here we use atomic-level simulations to elucidate the n...

Descrición completa

Gardado en:
Detalles Bibliográficos
Publicado en:Science
Main Authors: Dror, Ron O., Mildorf, Thomas J., Hilger, Daniel, Manglik, Aashish, Borhani, David W., Arlow, Daniel H., Philippsen, Ansgar, Villanueva, Nicolas, Yang, Zhongyu, Lerch, Michael T., Hubbell, Wayne L., Kobilka, Brian K., Sunahara, Roger K., Shaw, David E.
Formato: Artigo
Idioma:Inglês
Publicado: 2015
Assuntos:
Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4968074/
https://ncbi.nlm.nih.gov/pubmed/26089515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aaa5264
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares