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Mapping allosteric connections from the receptor to the nucleotide-binding pocket of heterotrimeric G proteins
Heterotrimeric G proteins function as molecular relays that mediate signal transduction from heptahelical receptors in the cell membrane to intracellular effector proteins. Crystallographic studies have demonstrated that guanine nucleotide exchange on the Gα subunit causes specific conformational ch...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2007
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1876549/ https://ncbi.nlm.nih.gov/pubmed/17463080 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0702623104 |
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