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A Transient Interaction between the Phosphate Binding Loop and Switch I Contributes to the Allosteric Network between Receptor and Nucleotide in Gα(i1)

Receptor-mediated activation of the Gα subunit of heterotrimeric G proteins requires allosteric communication between the receptor binding site and the guanine nucleotide binding site, which are separated by >30 Å. Structural changes in the allosteric network connecting these sites are predicted...

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Main Authors: Thaker, Tarjani M., Sarwar, Maruf, Preininger, Anita M., Hamm, Heidi E., Iverson, T. M.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Biochemistry and Molecular Biology 2014
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4036270/
https://ncbi.nlm.nih.gov/pubmed/24596087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.539064
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