Phosphorylation-induced Conformational Changes in Rap1b: ALLOSTERIC EFFECTS ON SWITCH DOMAINS AND EFFECTOR LOOP

Rap1b has been implicated in the transduction of the cAMP mitogenic response. Agonists that increase intracellular cAMP rapidly activate (i.e. GTP binding) and phosphorylate Rap1b on Ser(179) at its C terminus. cAMP-dependent protein kinase (PKA)-mediated phosphorylation of Rap1b is required for cAM...

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Detalhes bibliográficos
Main Authors: Edreira, Martin M., Li, Sheng, Hochbaum, Daniel, Wong, Sergio, Gorfe, Alemayehu A., Ribeiro-Neto, Fernando, Woods, Virgil L., Altschuler, Daniel L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Mechanisms of Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2785677/
https://ncbi.nlm.nih.gov/pubmed/19651783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.011312
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