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A Novel Epac-Rap-PP2A Signaling Module Controls cAMP-dependent Akt Regulation
Rap1b has been implicated in the transduction of the cAMP mitogenic signal. It is phosphorylated and activated by cAMP, and its expression in models where cAMP is mitogenic leads to proliferation and tumorigenesis. Akt is a likely downstream effector of cAMP-Rap1 action. cAMP elevation induced a rap...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2517008/ https://ncbi.nlm.nih.gov/pubmed/18550542 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M800478200 |
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