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Identification and Validation of Modulators of Exchange Protein Activated by cAMP (Epac) Activity: STRUCTURE-FUNCTION IMPLICATIONS FOR Epac ACTIVATION AND INHIBITION

The signaling molecule cAMP primarily mediates its effects by activating PKA and/or exchange protein activated by cAMP (Epac). Epac has been implicated in many responses in cells, but its precise roles have been difficult to define in the absence of Epac inhibitors. Epac, a guanine nucleotide exchan...

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Detalhes bibliográficos
Main Authors: Brown, Loren M., Rogers, Kathleen E., McCammon, J. Andrew, Insel, Paul A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3961650/
https://ncbi.nlm.nih.gov/pubmed/24497631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.548636
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