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Identification and Validation of Modulators of Exchange Protein Activated by cAMP (Epac) Activity: STRUCTURE-FUNCTION IMPLICATIONS FOR Epac ACTIVATION AND INHIBITION

The signaling molecule cAMP primarily mediates its effects by activating PKA and/or exchange protein activated by cAMP (Epac). Epac has been implicated in many responses in cells, but its precise roles have been difficult to define in the absence of Epac inhibitors. Epac, a guanine nucleotide exchan...

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Bibliografische gegevens
Hoofdauteurs: Brown, Loren M., Rogers, Kathleen E., McCammon, J. Andrew, Insel, Paul A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Biochemistry and Molecular Biology 2014
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3961650/
https://ncbi.nlm.nih.gov/pubmed/24497631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.548636
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