Role of Dynamics in the Autoinhibition and Activation of the Exchange Protein Directly Activated by Cyclic AMP (EPAC)

The exchange protein directly activated by cAMP (EPAC) is a key receptor of cAMP in eukaryotes and controls critical signaling pathways. Currently, no residue resolution information is available on the full-length EPAC dynamics, which are known to be pivotal determinants of allostery. In addition, n...

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Bibliografiske detaljer
Main Authors: VanSchouwen, Bryan, Selvaratnam, Rajeevan, Fogolari, Federico, Melacini, Giuseppe
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2011
Fag:
Signal Transduction
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3234915/
https://ncbi.nlm.nih.gov/pubmed/21873431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.277723
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