A Mechanism for the Auto-inhibition of Hyperpolarization-activated Cyclic Nucleotide-gated (HCN) Channel Opening and Its Relief by cAMP

Hyperpolarization-activated cyclic nucleotide-gated (HCN) ion channels control neuronal and cardiac electrical rhythmicity. There are four homologous isoforms (HCN1–4) sharing a common multidomain architecture that includes an N-terminal transmembrane tetrameric ion channel followed by a cytoplasmic...

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Main Authors: Akimoto, Madoka, Zhang, Zaiyong, Boulton, Stephen, Selvaratnam, Rajeevan, VanSchouwen, Bryan, Gloyd, Melanie, Accili, Eric A., Lange, Oliver F., Melacini, Giuseppe
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2014
Fag:
Signal Transduction
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4139233/
https://ncbi.nlm.nih.gov/pubmed/24878962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.572164
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