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Mechanism of cAMP Partial Agonism in Protein Kinase G (PKG)

Protein kinase G (PKG) is a major receptor of cGMP and controls signaling pathways often distinct from those regulated by cAMP. Hence, the selective activation of PKG by cGMP versus cAMP is critical. However, the mechanism of cGMP-versus-cAMP selectivity is only limitedly understood. Although the C-...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Main Authors: VanSchouwen, Bryan, Selvaratnam, Rajeevan, Giri, Rajanish, Lorenz, Robin, Herberg, Friedrich W., Kim, Choel, Melacini, Giuseppe
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4661378/
https://ncbi.nlm.nih.gov/pubmed/26370085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.685305
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