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Mechanism of cAMP Partial Agonism in Protein Kinase G (PKG)

Protein kinase G (PKG) is a major receptor of cGMP and controls signaling pathways often distinct from those regulated by cAMP. Hence, the selective activation of PKG by cGMP versus cAMP is critical. However, the mechanism of cGMP-versus-cAMP selectivity is only limitedly understood. Although the C-...

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Vydáno v:J Biol Chem
Hlavní autoři: VanSchouwen, Bryan, Selvaratnam, Rajeevan, Giri, Rajanish, Lorenz, Robin, Herberg, Friedrich W., Kim, Choel, Melacini, Giuseppe
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2015
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4661378/
https://ncbi.nlm.nih.gov/pubmed/26370085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.685305
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