Allosteric Inhibition of Epac: COMPUTATIONAL MODELING AND EXPERIMENTAL VALIDATION TO IDENTIFY ALLOSTERIC SITES AND INHIBITORS

Epac, a guanine nucleotide exchange factor for the low molecular weight G protein Rap, is an effector of cAMP signaling and has been implicated to have roles in numerous diseases, including diabetes mellitus, heart failure, and cancer. We used a computational molecular modeling approach to predict p...

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Detalhes bibliográficos
Main Authors: Brown, Loren M., Rogers, Kathleen E., Aroonsakool, Nakon, McCammon, J. Andrew, Insel, Paul A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Enzymology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4200268/
https://ncbi.nlm.nih.gov/pubmed/25183009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.569319
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