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Structural and dynamical changes in an α-subunit of a heterotrimeric G protein along the activation pathway
The Gα subunits of heterotrimeric G proteins (Gαβγ) mediate signal transduction via activation by receptors and subsequent interaction with downstream effectors. Crystal structures indicate that conformational changes in “switch” sequences of Gα, controlled by the identity of the bound nucleotide (G...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
National Academy of Sciences
2006
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1637559/ https://ncbi.nlm.nih.gov/pubmed/17053066 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0607972103 |
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