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Structural and dynamical changes in an α-subunit of a heterotrimeric G protein along the activation pathway

The Gα subunits of heterotrimeric G proteins (Gαβγ) mediate signal transduction via activation by receptors and subsequent interaction with downstream effectors. Crystal structures indicate that conformational changes in “switch” sequences of Gα, controlled by the identity of the bound nucleotide (G...

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Autors principals: Van Eps, Ned, Oldham, William M., Hamm, Heidi E., Hubbell, Wayne L.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2006
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1637559/
https://ncbi.nlm.nih.gov/pubmed/17053066
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0607972103
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