Interaction of a G protein with an activated receptor opens the interdomain interface in the alpha subunit

In G-protein signaling, an activated receptor catalyzes GDP/GTP exchange on the G(α) subunit of a heterotrimeric G protein. In an initial step, receptor interaction with G(α) acts to allosterically trigger GDP release from a binding site located between the nucleotide binding domain and a helical do...

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Detaylı Bibliyografya
Asıl Yazarlar: Van Eps, Ned, Preininger, Anita M., Alexander, Nathan, Kaya, Ali I., Meier, Scott, Meiler, Jens, Hamm, Heidi E., Hubbell, Wayne L.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2011
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3111277/
https://ncbi.nlm.nih.gov/pubmed/21606326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1105810108
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