Structural Basis for Nucleotide Exchange in Heterotrimeric G Proteins

G protein–coupled receptors (GPCRs) relay diverse extracellular signals into cells by catalyzing nucleotide release from heterotrimeric G proteins, but the mechanism underlying this quintessential molecular signaling event has remained unclear. Here we use atomic-level simulations to elucidate the n...

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Publicat a:Science
Autors principals: Dror, Ron O., Mildorf, Thomas J., Hilger, Daniel, Manglik, Aashish, Borhani, David W., Arlow, Daniel H., Philippsen, Ansgar, Villanueva, Nicolas, Yang, Zhongyu, Lerch, Michael T., Hubbell, Wayne L., Kobilka, Brian K., Sunahara, Roger K., Shaw, David E.
Format: Artigo
Idioma:Inglês
Publicat: 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4968074/
https://ncbi.nlm.nih.gov/pubmed/26089515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aaa5264
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