Activation mechanism of the β(2)-adrenergic receptor

A third of marketed drugs act by binding to a G-protein-coupled receptor (GPCR) and either triggering or preventing receptor activation. Although recent crystal structures have provided snapshots of both active and inactive functional states of GPCRs, these structures do not reveal the mechanism by...

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Detalhes bibliográficos
Main Authors: Dror, Ron O., Arlow, Daniel H., Maragakis, Paul, Mildorf, Thomas J., Pan, Albert C., Xu, Huafeng, Borhani, David W., Shaw, David E.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2011
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3219117/
https://ncbi.nlm.nih.gov/pubmed/22031696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1110499108
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