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Mechanism of allosteric regulation of β(2)-adrenergic receptor by cholesterol

There is evidence that lipids can be allosteric regulators of membrane protein structure and activation. However, there are no data showing how exactly the regulation emerges from specific lipid-protein interactions. Here we show in atomistic detail how the human β(2)-adrenergic receptor (β(2)AR) –...

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Bibliografski detalji
Izdano u:eLife
Glavni autori: Manna, Moutusi, Niemelä, Miia, Tynkkynen, Joona, Javanainen, Matti, Kulig, Waldemar, Müller, Daniel J, Rog, Tomasz, Vattulainen, Ilpo
Format: Artigo
Jezik:Inglês
Izdano: eLife Sciences Publications, Ltd 2016
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5182060/
https://ncbi.nlm.nih.gov/pubmed/27897972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.18432
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