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Mechanism of allosteric regulation of β(2)-adrenergic receptor by cholesterol

There is evidence that lipids can be allosteric regulators of membrane protein structure and activation. However, there are no data showing how exactly the regulation emerges from specific lipid-protein interactions. Here we show in atomistic detail how the human β(2)-adrenergic receptor (β(2)AR) –...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Manna, Moutusi, Niemelä, Miia, Tynkkynen, Joona, Javanainen, Matti, Kulig, Waldemar, Müller, Daniel J, Rog, Tomasz, Vattulainen, Ilpo
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5182060/
https://ncbi.nlm.nih.gov/pubmed/27897972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.18432
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