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Mechanism of allosteric regulation of β(2)-adrenergic receptor by cholesterol

There is evidence that lipids can be allosteric regulators of membrane protein structure and activation. However, there are no data showing how exactly the regulation emerges from specific lipid-protein interactions. Here we show in atomistic detail how the human β(2)-adrenergic receptor (β(2)AR) –...

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Bibliografische gegevens
Gepubliceerd in:eLife
Hoofdauteurs: Manna, Moutusi, Niemelä, Miia, Tynkkynen, Joona, Javanainen, Matti, Kulig, Waldemar, Müller, Daniel J, Rog, Tomasz, Vattulainen, Ilpo
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: eLife Sciences Publications, Ltd 2016
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5182060/
https://ncbi.nlm.nih.gov/pubmed/27897972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.18432
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