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Identification of two distinct inactive conformations of the β(2)-adrenergic receptor reconciles structural and biochemical observations

Fully understanding the mechanisms of signaling proteins such as G protein-coupled receptors (GPCRs) will require the characterization of their conformational states and the pathways connecting those states. The recent crystal structures of the β(2)- and β(1)-adrenergic receptors in a nominally inac...

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Detalhes bibliográficos
Main Authors: Dror, Ron O., Arlow, Daniel H., Borhani, David W., Jensen, Morten Ø., Piana, Stefano, Shaw, David E.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2650503/
https://ncbi.nlm.nih.gov/pubmed/19258456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0811065106
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