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Pathway and mechanism of drug binding to G-protein-coupled receptors
How drugs bind to their receptors—from initial association, through drug entry into the binding pocket, to adoption of the final bound conformation, or “pose”—has remained unknown, even for G-protein-coupled receptor modulators, which constitute one-third of all marketed drugs. We captured this phar...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3156183/ https://ncbi.nlm.nih.gov/pubmed/21778406 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1104614108 |
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