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Pathway and mechanism of drug binding to G-protein-coupled receptors

How drugs bind to their receptors—from initial association, through drug entry into the binding pocket, to adoption of the final bound conformation, or “pose”—has remained unknown, even for G-protein-coupled receptor modulators, which constitute one-third of all marketed drugs. We captured this phar...

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Bibliografische gegevens
Hoofdauteurs: Dror, Ron O., Pan, Albert C., Arlow, Daniel H., Borhani, David W., Maragakis, Paul, Shan, Yibing, Xu, Huafeng, Shaw, David E.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2011
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3156183/
https://ncbi.nlm.nih.gov/pubmed/21778406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1104614108
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