G(i)- and G(s)-coupled GPCRs show different modes of G-protein binding

More than two decades ago, the activation mechanism for the membrane-bound photoreceptor and prototypical G protein-coupled receptor (GPCR) rhodopsin was uncovered. Upon light-induced changes in ligand–receptor interaction, movement of specific transmembrane helices within the receptor opens a crevi...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Proc Natl Acad Sci U S A
Egile Nagusiak: Van Eps, Ned, Altenbach, Christian, Caro, Lydia N., Latorraca, Naomi R., Hollingsworth, Scott A., Dror, Ron O., Ernst, Oliver P., Hubbell, Wayne L.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: National Academy of Sciences 2018
Gaiak:
Biological Sciences
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5877964/
https://ncbi.nlm.nih.gov/pubmed/29463720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1721896115
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