G(i)- and G(s)-coupled GPCRs show different modes of G-protein binding

More than two decades ago, the activation mechanism for the membrane-bound photoreceptor and prototypical G protein-coupled receptor (GPCR) rhodopsin was uncovered. Upon light-induced changes in ligand–receptor interaction, movement of specific transmembrane helices within the receptor opens a crevi...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Van Eps, Ned, Altenbach, Christian, Caro, Lydia N., Latorraca, Naomi R., Hollingsworth, Scott A., Dror, Ron O., Ernst, Oliver P., Hubbell, Wayne L.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2018
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5877964/
https://ncbi.nlm.nih.gov/pubmed/29463720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1721896115
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