Allosteric coupling from G protein to the agonist binding pocket in GPCRs

G protein-coupled receptors (GPCRs) remain the primary conduit by which cells detect environmental stimuli and communicate with each other(1). Upon activation by extracellular agonists, these seven transmembrane domain (7TM)-containing receptors interact with heterotrimeric G proteins to regulate do...

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Detalhes bibliográficos
Publicado no:Nature
Main Authors: DeVree, Brian T., Mahoney, Jacob P., Vélez-Ruiz, Gisselle A., Rasmussen, Soren G.F., Kuszak, Adam J., Edwald, Elin, Fung, Juan-Jose, Manglik, Aashish, Masureel, Matthieu, Du, Yang, Matt, Rachel A, Pardon, Els, Steyaert, Jan, Kobilka, Brian K., Sunahara, Roger K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5702553/
https://ncbi.nlm.nih.gov/pubmed/27362234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature18324
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