Cryptic pocket formation underlies allosteric modulator selectivity at muscarinic GPCRs

Allosteric modulators are highly desirable as drugs, particularly for G-protein-coupled receptor (GPCR) targets, because allosteric drugs can achieve selectivity between closely related receptors. The mechanisms by which allosteric modulators achieve selectivity remain elusive, however, particularly...

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Xehetasun bibliografikoak
Argitaratua izan da:Nat Commun
Egile Nagusiak: Hollingsworth, Scott A., Kelly, Brendan, Valant, Celine, Michaelis, Jordan Arthur, Mastromihalis, Olivia, Thompson, Geoff, Venkatakrishnan, A. J., Hertig, Samuel, Scammells, Peter J., Sexton, Patrick M., Felder, Christian C., Christopoulos, Arthur, Dror, Ron O.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group UK 2019
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6650467/
https://ncbi.nlm.nih.gov/pubmed/31337749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-11062-7
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