Cryptic pocket formation underlies allosteric modulator selectivity at muscarinic GPCRs

Allosteric modulators are highly desirable as drugs, particularly for G-protein-coupled receptor (GPCR) targets, because allosteric drugs can achieve selectivity between closely related receptors. The mechanisms by which allosteric modulators achieve selectivity remain elusive, however, particularly...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Hollingsworth, Scott A., Kelly, Brendan, Valant, Celine, Michaelis, Jordan Arthur, Mastromihalis, Olivia, Thompson, Geoff, Venkatakrishnan, A. J., Hertig, Samuel, Scammells, Peter J., Sexton, Patrick M., Felder, Christian C., Christopoulos, Arthur, Dror, Ron O.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6650467/
https://ncbi.nlm.nih.gov/pubmed/31337749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-11062-7
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados