Cryptic pocket formation underlies allosteric modulator selectivity at muscarinic GPCRs

Allosteric modulators are highly desirable as drugs, particularly for G-protein-coupled receptor (GPCR) targets, because allosteric drugs can achieve selectivity between closely related receptors. The mechanisms by which allosteric modulators achieve selectivity remain elusive, however, particularly...

全面介紹

Na minha lista:
書目詳細資料
發表在:Nat Commun
Main Authors: Hollingsworth, Scott A., Kelly, Brendan, Valant, Celine, Michaelis, Jordan Arthur, Mastromihalis, Olivia, Thompson, Geoff, Venkatakrishnan, A. J., Hertig, Samuel, Scammells, Peter J., Sexton, Patrick M., Felder, Christian C., Christopoulos, Arthur, Dror, Ron O.
格式: Artigo
語言:Inglês
出版: Nature Publishing Group UK 2019
主題:
Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6650467/
https://ncbi.nlm.nih.gov/pubmed/31337749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-11062-7
標簽: 添加標簽
沒有標簽, 成為第一個標記此記錄!

相似書籍